Polynucleotides Espoo

Polynucleotides are the latest innovation in active ingredients for mesotherapy. They brighten the skin and make it firm, supple, and smooth. The treatment is usually administered as a series of three sessions on the under-eye area, face, neck, and sometimes even the décolleté. Results develop over the course of the treatment series and peak 8–12 weeks after the series is completed.

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Polynucleotides: A Brief Overview

Polynucleotides support skin regeneration and its natural repair processes. They are injected into the skin in dozens of microdoses, just like other active ingredients used in mesotherapy. Polynucleotides are derived from salmon DNA. They are not suitable for people with fish allergies.

Polynucleotides are DNA fragments that support cellular regeneration and the body’s own tissue repair processes. By activating fibroblasts, they stimulate the production of new collagen and elastin.

Polynucleotide treatment begins with a skin analysis and continues with the development of a personalized treatment plan. During the procedure itself, polynucleotides are injected into the treatment area in dozens of microdoses.

Polynucleotides gradually improve the condition and appearance of the skin. The skin becomes smoother and firmer, and its ability to regenerate improves.

Results continue to improve during the course of treatment and for another 2–3 months after the course is completed. The effects last for several months. The need for and timing of maintenance treatments are determined on an individual basis.

Polynucleotide therapy is a type of mesotherapy. Possible side effects of the procedure include swelling, redness, or minor bruising. These symptoms usually subside within a few days.

Polynucleotide treatment at VM Aesthetics

Cost of polynucleotide therapy

VM Aesthetics

Ameela polynucleotides1 treatmentA course of 3 treatments
Under-eye area270 €770 €
Face or neck570 €1500 €
Face and neck700 €1900 €
Cosmetic Botox during the same visit€100 per area

Polynucleotides are most effective when administered as a course of treatment.

Treatment is usually administered 2–3 times at intervals of 2–4 weeks.

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Customer experiences

Microneedling, mesotherapy, and polynucleotides

Essi is always a friendly and reliable professional who is easy to talk to. Thank you!
Customer Feedback, 2025
The service at Essi's was excellent. Professional, calm, and warm service throughout the treatment.
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Essi is always a friendly and reliable professional who is easy to talk to. Thank you!
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Are you interested in polynucleotides? Schedule a free, no-obligation consultation. The consultation can also be conducted via photos.

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Polynucleotides regenerate and repair the skin

Polynucleotides are suitable for adult women and men.
People often seek polynucleotide treatment when their skin looks tired and thin, or even more saggy than before.

Treatment topics:

  • dry, thinning skin
  • skin sagging, loss of skin elasticity (resilience/ability to bounce back)
  • dull skin
  • superficial wrinkles and fine lines
  • changes around the eyes (dark circles, puffiness, slight bags)

If the goal is to achieve a noticeable increase in volume or to contour facial features, dermal filler treatment is usually the first choice.

What polynucleotides do and what they don't do

  • In polynucleotide therapy, DNA-derived molecules are injected into the dermis, or the layer of skin beneath the epidermis. These molecules act within the dermal extracellular matrix, where they support the tissue’s own repair processes.
  • The treatment improves the skin's moisture balance and stimulates collagen and elastin synthesis.
  • Polynucleotides also act as antioxidants and can reduce oxidative stress in the skin.
  • The treatment does not plump up the tissues or alter facial features, but rather improves the condition and appearance of the skin.

Polynucleotides, Espoo, Dr. Laura Juopperi

How does polynucleotide therapy work?

Polynucleotide treatment begins with a relaxed consultation and planning for the procedure, if necessary. The treatment is quick and is generally well tolerated. However, some discomfort is possible; patients often describe the sensation as a pinching or stinging feeling during the injections.

Consultation

Polynucleotide treatment begins with a thorough consultation. You can book a free consultation appointment even while you’re still considering treatment. During the consultation, you can ask questions, discuss your treatment goals, and meet our professionals. At the same time, we will assess the treatment area and select the polynucleotide product best suited to your situation.

A separate consultation visit is not required. We consult with all clients before proceeding with treatment, and if it is determined during the appointment that treatment cannot be performed, the visit automatically becomes a free consultation.

Polynucleotide injections

After the consultation, we will proceed with the procedure. The skin in the treatment area will be cleaned before the procedure. If necessary, a numbing cream will be applied to the area.

In polynucleotide therapy, small amounts of polynucleotide solution are administered into the skin using fine needles. The injections are administered superficially and evenly into the skin of the treatment area.

Polynucleotides for injection into the face and neck 

  • stimulate fibroblasts, which produce new collagen
  • have antioxidant properties, meaning they prevent skin damage caused by free radicals
  • lock moisture into the skin

Polynucleotides for injection under the eyes

  • firm the skin and gently plump it
  • stimulate fluid and blood circulation
  • lock in moisture for thin, easily wrinkled skin

After polynucleotide therapy

After polynucleotide treatment, the skin is cleaned and the injection sites are checked. Small injection marks and raised areas, resembling mosquito bites, often remain on the skin. These will flatten out within the first few hours or, at the latest, within the first few days.

Swelling, redness, and tenderness often develop in the treated area. Bruising is also possible, especially under the eyes. It may take several days for the bruises to fade, sometimes even more than a week.

Unless you experience any lingering symptoms, you can return to your normal routine after the procedure. However, you should avoid touching the treated area, applying makeup, strenuous exercise, alcohol, and saunas for at least the first 24 hours.

Aftercare instructions are reviewed verbally during the appointment. The client also receives a written copy of the aftercare instructions to take home.

When will the results be available?

Polynucleotides do not produce immediate results. The treatment works by activating the skin’s own regeneration and repair processes. Therefore, results develop gradually during and after the course of treatment.

  • The first changes will be visible a few weeks after starting the treatment regimen
  • The most noticeable effect appears 6–12 weeks after the end of the treatment course
  • The results are primarily based on the formation of new collagen and elastin

The results of polynucleotide therapy improve with repeated treatment

The effects of polynucleotide therapy are not immediate but gradual. The best and most lasting results are achieved through a series of treatments. The therapeutic outcome develops gradually both during and after the treatments.

Individual factors influence the progression of treatment results: age, health status, skin condition, and the number of treatment sessions. A single treatment session may produce a slight change in the skin, but the most noticeable results are typically seen only after several sessions.

  • No immediate results: the effects develop over the course of several weeks
  • Series of treatments: typically 3 sessions every 2–4 weeks
  • Effect: based on the regeneration of collagen and elastin
  • Duration: The results typically last for about 6–9 months

The results can be maintained with individual polynucleotide treatments, which can be administered every 6 to 12 months, for example.

Free consultation

Are you interested in polynucleotides? Schedule a free, no-obligation consultation. The consultation can also be conducted via photos.

Book an appointmentPhoto consultation

Frequently Asked Questions About Polynucleotides

What is polynucleotide therapy?

Polynucleotide therapy is a form of mesotherapy in which DNA-derived molecules are introduced into the skin. The treatment accelerates the skin’s repair processes and promotes comprehensive skin regeneration.

What is polynucleotide therapy used for?

Polynucleotide therapy is particularly suitable for treating the skin on the face, neck, and under the eyes when the goal is to stimulate the skin’s natural repair processes and improve its condition and appearance.

How do polynucleotides differ from fillers?

Fillers plump up facial features, whereas polynucleotides do not alter facial features. The effect of polynucleotides is based on stimulating collagen production and accelerating skin regeneration.

Does polynucleotide therapy hurt?

The treatment usually feels like a pinching or stinging sensation. The discomfort is brief, and an anesthetic cream is used if necessary.

How quickly does polynucleotide therapy take effect?

Polynucleotide therapy does not produce immediate results. The first changes become apparent within a few weeks, and the most noticeable effects develop approximately 6–12 weeks after the completion of the treatment course.

How many polynucleotide treatments are needed?

The best results are usually achieved with a course of treatments. Typically, 3 treatments are administered every 2–4 weeks.

How long do the results of polynucleotide therapy last?

The results usually last about 6–9 months. After that, the effects can be maintained with follow-up treatments.

What does the skin look like after polynucleotide treatment?

Small injection marks and bumps may remain on the skin. In addition, swelling, redness, and tenderness may occur, and sometimes bruising as well.

How long do the aftereffects last?

Minor swelling and bruising usually subside within a few hours or a day. Bruises may last for more than a week, especially in sensitive areas.

Can I go to work after receiving polynucleotide therapy?

Yes, you can. Most people return to their normal daily routine right away. However, swelling or bruising may still be visible.

What should you avoid doing after polynucleotide therapy?

It is recommended that you avoid wearing makeup, using the sauna, engaging in strenuous exercise, and drinking alcohol for the first 24 hours.

What are the side effects of polynucleotide therapy?

The most common side effects are swelling, redness, tenderness, and bruising. These are normal and temporary reactions.

Who is a good candidate for polynucleotide therapy?

Polynucleotides are suitable for people who want to boost their skin’s natural renewal process, stimulate collagen production, and reduce dark circles and puffiness under the eyes.

Free consultation

Are you interested in polynucleotides? Schedule a free, no-obligation consultation. The consultation can also be conducted via photos.

Book an appointmentPhoto consultation

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